Title of Project:
Association study between candidate genes and antibodies against Malaria
The aim of this study is to analyze the relationship between different candidate genes and antibodies against three antigens from Plasmodium falciparum, one of the most lethal parasites causing Malaria. The study will be conducted in a data set of more than 7,000 individuals collected in northeastern Tanzania in East Africa (Drakeley et al, 2005; Enevold et al, 2007; Sepúlveda et al, 2017).
Drakeley CJ, Corran PH, Coleman PG, Tongren JE, McDonald SL, Carneiro I, Malima R, Lusingu J, Manjurano A, Nkya WM, Lemnge MM, Cox J, Reyburn H, Riley EM. Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc Natl Acad Sci U S A. 2005;102(14):5108-13.
Enevold A, Alifrangis M, Sanchez JJ, Carneiro I, Roper C, Børsting C, Lusingu J, Vestergaard LS, Lemnge MM, Morling N, Riley E, Drakeley CJ. Associations between alpha+-thalassemia and Plasmodium falciparum malarial infection in northeastern Tanzania. J Infect Dis. 2007;196(3):451-9.
Sepúlveda N, Manjurano A, Campino SG, Lemnge M, Lusingu J, Olomi R, Rockett KA, Hubbart C, Jeffreys A, Rowlands K, Clark TG, Riley EM, Drakeley CJ; MalariaGEN Consortium. Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity. J Infect Dis. 2017;216(1):45-54.